Here's my concern about HRT for women: estrogen and testosterone have ester versions that extend their half life, making them much more convenient. Progresterone? Nope, there are currently no way to extend its half life beyond 1 day due to a lack of hydroxyl groups. If the women taking progesterone misses a day for some reason, she can bleed the next day as her levels plummet, and it sucks. I had read some research on some potential alternatives that utilize ethers and oximes.
@christersmith5470